Endothelial Dysfunction Biomarkers After Pregnancy With GDM
Endothelial Dysfunction Biomarkers After Pregnancy With GDM
In summary, we found that biomarkers of endothelial dysfunction are related to impaired insulin sensitivity and moreover notably increased in females with recent history of GDM. Thereby sICAM-1 and sE-selectin tended to be elevated in subjects who showed a progression to type 2 diabetes after delivery and hence possibly indicate the later development of overt cardiometabolic disorders in this relatively young aged risk population. Follow-up examinations with clearly defined cardiovascular endpoints as well as randomized trials are necessary to further examine clinical consequences and possible therapeutic approaches. However, our results indicate a need of early risk stratification immediately after delivery. Clinical re-examinations including risk factor modification and patient education might represent an opportunity to prevent disease progression in females with history of gestational hyperglycemia.
Conclusions
In summary, we found that biomarkers of endothelial dysfunction are related to impaired insulin sensitivity and moreover notably increased in females with recent history of GDM. Thereby sICAM-1 and sE-selectin tended to be elevated in subjects who showed a progression to type 2 diabetes after delivery and hence possibly indicate the later development of overt cardiometabolic disorders in this relatively young aged risk population. Follow-up examinations with clearly defined cardiovascular endpoints as well as randomized trials are necessary to further examine clinical consequences and possible therapeutic approaches. However, our results indicate a need of early risk stratification immediately after delivery. Clinical re-examinations including risk factor modification and patient education might represent an opportunity to prevent disease progression in females with history of gestational hyperglycemia.
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