Salvestrols Against Thyroid Cancer
In studies against thyroid cancer cell lines, salvestrol T31G and salvestrol Q40 were the most effective inhibitors found. These 2 salvestrols have been formulated together in the supplement Salvestrol Platinum. Salvestrol T31G was shown to inhibit thyroid cancer cell signal transduction and induce apoptosis. The scientists concluded that salvestrol T31G may provide a new approach for the treatment of human anaplastic thyroid carcinoma for which no effective therapy is presently available.
Another study compared the effects of genistein, salvestrol T31G, salvestrol Q40, chrysin and other flavonoids on human thyroid carcinoma cell lines. Among the flavonoids tested, salvestrol T31G and salvestrol Q40 were shown to be the most potent inhibitors of these cancer cell lines. Because these thyroid cancer cells lacked an anti-estrogen receptor binding site and an estrogen receptor, that salvestrol T31G and salvestrol Q40 are inhibiting these cancer cells via mechanisms involving CYP1B1 bioactivation. The scientists concluded that salvestrol T31G and salvestrol Q40 may represent a new class of therapeutic agents in the management of thyroid cancer.
Cancer prevention and treatment
anticarcinogenic, antimutagenic, antiangiogenic properties
Salvestrol Q40 in the low micromolar range inhibits the proliferation of normal and tumor cells, as well as in vitro angiogenesis. Inhibition of extensive neovascularization can contribute to prevention of certain chronic diseases, including solid malignancies. Salvestrol Q40 shows strong antiproliferative activity against different human cancer cell lines and in some hormone-dependent cancer lines such as breast, prostate, and thyroid cancer for instance.
The CYP1B1 metabolite Salvestrol Q50 potently inhibits many tyrosine kinases, enzymes that are involved in tumor cell proliferation. This enables the toxicity of salvestrols to be specifically directed at the thyroid cancer cells making this a rational approach to the treatment of thyroid cancer.
Salvestrols are natural anticancer molecules present in the human diet. They are activated inside tumour cells to anticancer metabolites that destroy the cancer from within. The enzyme that activates them is called Beta Salvestrol Activase also known as CYP1B1. This enzyme is expressed in every form of human cancer. Each cancer cell has the CYP1B1 enzyme that has been likened to a Trojan Horse within the tumour cell. When the salvestrols reach the tumour they encounter the trojan horse and release a stream of deadly chemicals killing the tumour cells and destroying the tumour. There are 100 salvestrols in total in five different classes alpha, beta, gamma, delta and omega. It is the omega salvestrols that ultimately destroy the tumour. When salvestrols reach the liver they are salvaged and returned to the bloodstream for re-delivery to the tumour, hence the name salvestrols from the Latin word "salve" which means "to save". The alpha salvestrols are present in red fruits such as grapes and one example is the red wine constituent resveratrol. Resveratrol is salvestrol S30 and 10 others are important in the diet. Salvestrol Q40 is the most potent of these and is found in high concentrations in brassica vegetables and citrus fruit such as oranges. Salvestrol Therapy is the use of salvestrols to combat cancer. For Salvestrol therapy a high strength supplement such as Salvestrol Platinum (2000 points) is taken 3 times daily after meals. Case studies have shown Salvestrols to be effective against a wide variety of cancers including breast, brain, bladder, cervical, colon, liver, lung, skin, ovarian, prostate, testicular, thyroid, and pancreatic cancer.
Another study compared the effects of genistein, salvestrol T31G, salvestrol Q40, chrysin and other flavonoids on human thyroid carcinoma cell lines. Among the flavonoids tested, salvestrol T31G and salvestrol Q40 were shown to be the most potent inhibitors of these cancer cell lines. Because these thyroid cancer cells lacked an anti-estrogen receptor binding site and an estrogen receptor, that salvestrol T31G and salvestrol Q40 are inhibiting these cancer cells via mechanisms involving CYP1B1 bioactivation. The scientists concluded that salvestrol T31G and salvestrol Q40 may represent a new class of therapeutic agents in the management of thyroid cancer.
Cancer prevention and treatment
anticarcinogenic, antimutagenic, antiangiogenic properties
Salvestrol Q40 in the low micromolar range inhibits the proliferation of normal and tumor cells, as well as in vitro angiogenesis. Inhibition of extensive neovascularization can contribute to prevention of certain chronic diseases, including solid malignancies. Salvestrol Q40 shows strong antiproliferative activity against different human cancer cell lines and in some hormone-dependent cancer lines such as breast, prostate, and thyroid cancer for instance.
The CYP1B1 metabolite Salvestrol Q50 potently inhibits many tyrosine kinases, enzymes that are involved in tumor cell proliferation. This enables the toxicity of salvestrols to be specifically directed at the thyroid cancer cells making this a rational approach to the treatment of thyroid cancer.
Salvestrols are natural anticancer molecules present in the human diet. They are activated inside tumour cells to anticancer metabolites that destroy the cancer from within. The enzyme that activates them is called Beta Salvestrol Activase also known as CYP1B1. This enzyme is expressed in every form of human cancer. Each cancer cell has the CYP1B1 enzyme that has been likened to a Trojan Horse within the tumour cell. When the salvestrols reach the tumour they encounter the trojan horse and release a stream of deadly chemicals killing the tumour cells and destroying the tumour. There are 100 salvestrols in total in five different classes alpha, beta, gamma, delta and omega. It is the omega salvestrols that ultimately destroy the tumour. When salvestrols reach the liver they are salvaged and returned to the bloodstream for re-delivery to the tumour, hence the name salvestrols from the Latin word "salve" which means "to save". The alpha salvestrols are present in red fruits such as grapes and one example is the red wine constituent resveratrol. Resveratrol is salvestrol S30 and 10 others are important in the diet. Salvestrol Q40 is the most potent of these and is found in high concentrations in brassica vegetables and citrus fruit such as oranges. Salvestrol Therapy is the use of salvestrols to combat cancer. For Salvestrol therapy a high strength supplement such as Salvestrol Platinum (2000 points) is taken 3 times daily after meals. Case studies have shown Salvestrols to be effective against a wide variety of cancers including breast, brain, bladder, cervical, colon, liver, lung, skin, ovarian, prostate, testicular, thyroid, and pancreatic cancer.
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