Severe Hyperglycemia in Critically Ill Children Post Surgery
Severe Hyperglycemia in Critically Ill Children Post Surgery
We conclude that critically ill children with severe hyperglycemia initially have reduced β-cell function and insulin sensitivity. β-cell function recovers rapidly but peripheral resistance to insulin persists. There was no relationship between glycemia and the majority of the hormonal changes detected. Patients who died had higher cortisol and growth hormone levels and developed hyperglycemia later than survivors. There was no relationship between glycemia and mortality although the number of patients is too small to detect differences. Length of stay was associated with C-peptide, insulin, and blood glucose levels, insulin resistance, and severity of illness at 24 hours.
Conclusions
We conclude that critically ill children with severe hyperglycemia initially have reduced β-cell function and insulin sensitivity. β-cell function recovers rapidly but peripheral resistance to insulin persists. There was no relationship between glycemia and the majority of the hormonal changes detected. Patients who died had higher cortisol and growth hormone levels and developed hyperglycemia later than survivors. There was no relationship between glycemia and mortality although the number of patients is too small to detect differences. Length of stay was associated with C-peptide, insulin, and blood glucose levels, insulin resistance, and severity of illness at 24 hours.
Source...