Acute Kidney Injury Due to Anti-tuberculosis Drugs
Acute Kidney Injury Due to Anti-tuberculosis Drugs
Anti-tuberculosis drug-induced acute kidney injury is not rare in an aging population. It usually develops within two months of treatment and resolves within three months after onset. Although about 27% of patients with AKI will have permanent renal impairment, those who present with fever, rash, and GI disturbance at the onset of AKI have better renal recovery. Of the 73% of patients who had recovery of renal function, 87% successfully continued rifampicin or had rifampicin re-introduced.
The study was approved by the Institutional Review Board of National Taiwan University Hospital (NTUH_IRB: 9561707008).
Tuberculosis is a global disease affecting one-third of the world's population. Acute kidney injury is not uncommon in patients receiving anti-tuberculosis drugs. Identifying risk and prognostic factors of acute kidney injury is important in the management of tuberculosis.
Conclusions
Anti-tuberculosis drug-induced acute kidney injury is not rare in an aging population. It usually develops within two months of treatment and resolves within three months after onset. Although about 27% of patients with AKI will have permanent renal impairment, those who present with fever, rash, and GI disturbance at the onset of AKI have better renal recovery. Of the 73% of patients who had recovery of renal function, 87% successfully continued rifampicin or had rifampicin re-introduced.
Ethical Approval
The study was approved by the Institutional Review Board of National Taiwan University Hospital (NTUH_IRB: 9561707008).
Summary
Tuberculosis is a global disease affecting one-third of the world's population. Acute kidney injury is not uncommon in patients receiving anti-tuberculosis drugs. Identifying risk and prognostic factors of acute kidney injury is important in the management of tuberculosis.
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