Common Side Effects

• Common side effects include nausea and vomiting, constipation, anxiety, dizziness, fatigue, insomnia and nightmares, weakness and dry mouth. It may also cause blurred vision, difficulty concentrating, decreased sex drive and ringing in the ears.
  
  

Serious Side Effects

• Potentially serious side effects include high blood pressure, hallucinations, stroke, increased depression, liver disease, heart conditions and psychosis. Certain conditions such as recent heart disease or liver problems can increase the risk of complications.
  
  

Interactions

• Drinking alcohol while taking desipramine can greatly increase the risk of life-threatening side effects. Medications such as antihistamines, muscle relaxers, sedatives and cold medicines can increase drowsiness. Consumption of grapefruit may decrease the effectiveness of desipramine.
  
  

Suicide

• Desipramine can increase the risk of suicide in children, adolescents and young adults with a history of severe depression. The risk is highest in the first month of taking the medication.
  
  

Overdose

• Signs of overdose include uneven heartbeats, extreme tiredness, hallucinations, seizures, confusion and coma. Taking too much desipramine can be fatal. Seek help immediately if you suspect an overdose.