Coffee Consumption, the Metabolic Syndrome, and NAFLD
Coffee Consumption, the Metabolic Syndrome, and NAFLD
A literature search was conducted with the aim of finding original experimental, epidemiological and clinical articles on the association between coffee consumption, MetS and NAFLD. The following databases were used: PubMed, Embase, Scopus and Science Direct. We included articles written in English and published up to July 2013. The terms used in the searches were as follows: coffee, coffee consumption, metabolic syndrome, insulin resistance syndrome, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and other terms related to experimental, epidemiological and clinical studies. The search strategy used in PubMed is shown in Table 1. Additional papers were identified in the reference lists of selected articles that met the inclusion criteria. All articles were read in full. Two independent investigators assessed papers for inclusion in a parallel manner. Three primary outcome measures were used for this review: (i) the experimental evidence linking coffee intake with MetS and fatty liver infiltration in animal models; (ii) the epidemiological and clinical evidence on the association between coffee consumption and the risk of MetS; (iii) the epidemiological and clinical evidence on the association between coffee consumption and the risk of NAFLD.
Literature Search and Search Strategy
A literature search was conducted with the aim of finding original experimental, epidemiological and clinical articles on the association between coffee consumption, MetS and NAFLD. The following databases were used: PubMed, Embase, Scopus and Science Direct. We included articles written in English and published up to July 2013. The terms used in the searches were as follows: coffee, coffee consumption, metabolic syndrome, insulin resistance syndrome, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and other terms related to experimental, epidemiological and clinical studies. The search strategy used in PubMed is shown in Table 1. Additional papers were identified in the reference lists of selected articles that met the inclusion criteria. All articles were read in full. Two independent investigators assessed papers for inclusion in a parallel manner. Three primary outcome measures were used for this review: (i) the experimental evidence linking coffee intake with MetS and fatty liver infiltration in animal models; (ii) the epidemiological and clinical evidence on the association between coffee consumption and the risk of MetS; (iii) the epidemiological and clinical evidence on the association between coffee consumption and the risk of NAFLD.
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