Mania

• Antidepressant medications, including Zoloft, can induce a manic episode. A mood stabilizer is typically prescribed for individuals with Bipolar Disorder, and this can help prevent a manic episode when prescribed with Zoloft.
  
  

Unstable Mood

• Zoloft may cause an increase in frequently and severity of mood cycling in Bipolar Disorer.
  
  

Drug Interactions

• Mood stabilizers, including Lamictal, can interact with Zoloft and increase the risk of developing side effects, including neck pain, upset stomach, etc.
  
  

Depressive Episodes

• Zoloft can help alleviate depressive symptoms during the depressive episodes of Bipolar Disorder. A mood stabilizer, if not already prescribed, should be considered to lessen the risk of a manic episode.
  
  

Treatment Options

• Other treatment options should be considered prior to prescribing Zoloft for individuals with Bipolar Disorder. If no medications are prescribed, a mood stabilizer should be considered. If one is already prescribed, altering the dose or trying a different mood stabilizer is an option. Making lifestyle changes or attending therapy may be helpful in lieu of or in conjunction with Zoloft with Bipolar Disorder.